I have been on the patch and then Oxy for about 5 years now. I have a history of depression and now just today I found out when I called my psych that the pain meds actually cause depression by lowering the natural serotonin. I see by reading the last posts that many of you already know about this. So what am I to do? I can't stand the pain but would rather have physical pain than the agony and pain of major depression. Will antidepressants put it right again? I used to be on Serzone, it was the only anti-d that I could tolerate. If I managed to get off the meds how long will it take to get my head back. I haven't heard myself laugh in months